The correlation between protein stability and dipole moment: a critical test

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The correlation between protein stability and dipole moment: a critical test.

Improving the stability of proteins is a major aim in basic and applied protein science. Querol and coworkers calculated changes in the quasi-electric dipole moment of a protein and used it as a simple criterion to predict stabilizing charge mutations. They employed this method to propose for the bacterial cold shock protein Bc-Csp a number of charge mutations that should have a strong influenc...

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ژورنال

عنوان ژورنال: Protein Engineering Design and Selection

سال: 2006

ISSN: 1741-0126,1741-0134

DOI: 10.1093/protein/gzl019